Πλοήγηση ανά Θέμα "Autoimmune Diseases"
Αποτελέσματα 1-20 από 22
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Alpha-actinin: A multidisciplinary protein with important role in B-cell driven autoimmunity
(2011)Alpha-actinin (α-actinin) is a ubiquitous cytoskeletal protein, which belongs to the superfamily of filamentous actin (F-actin) crosslinking proteins. It is present in multiple subcellular regions of both muscle and ... -
The challenges of primary biliary cholangitis: What is new and what needs to be done
(2019)Primary Biliary Cholangitis (PBC) is an uncommon, chronic, cholangiopathy of autoimmune origin and unknown etiology characterized by positive anti-mitochondrial autoantibodies (AMA), female preponderance and progression ... -
Decreased serum DNase1-activity in patients with autoimmune liver diseases
(2017)Deoxyribonuclease1 (DNase1) is involved in chromatin degradation of apoptotic cells. Its deficiency results in accumulation of self-DNA, which in turn may induce inflammation and autoimmunity. We assessed for the first ... -
Exploring the potential of mucin 13 (MUC13) as a biomarker for carcinomas and other diseases
(2018)Mucin 13 (MUC13) is a cell surface glycoprotein aberrantly expressed in a variety of epithelial carcinomas. Thus far, the role of MUC13 in various diseases remains elusive. To the best of our knowledge, this is the first ... -
From microbiome to infectome in autoimmunity
(2017)Purpose of review The current review discusses the pros and cons of the microbiome studies conducted in search of the association between microbiota and autoimmunity. Recent findings We focus on the role of infectome and ... -
Genetics of Hereditary Angioedema Revisited
(2016)Contemporary genetic research has provided evidences that angioedema represents a diverse family of disorders related to kinin metabolism, with a much greater genetic complexity than was initially considered. Convincing ... -
IL-35: a new immunomodulator in autoimmune rheumatic diseases
(2018)IL-35 is a relatively new cytokine that emerges as an important immunomodulator. IL-35 belongs to IL-12 cytokine family that includes IL-12, IL-23, IL-27, and IL-35. These cytokines are heterodimers that share subunits and ... -
Increased primary autoimmune thyroid diseases and thyroid antibodies in sarcoidosis: Evidence for an under-recognised extrathoracic involvement in sarcoido
(2012)Objective and Design: Sarcoidosis has been associated with thyroid diseases. However, until today no definite conclusions have been drawn. We aimed to assess the frequency of thyroid disorders and the levels of thyroid ... -
Molecular diagnostic testing for primary biliary cholangitis
(2016)Introduction: A reliable liver autoimmune serology for the diagnosis of primary biliary cholangitis (PBC) is of particular importance. Recognition of patients at early stages and prompt treatment initiation may alter the ... -
Novel Cell-Based Assay for Alpha-3 Nicotinic Receptor Antibodies Detects Antibodies Exclusively in Autoimmune Autonomic Ganglionopathy
(2022)BACKGROUND AND OBJECTIVES: Autoantibodies against α3-subunit-containing nicotinic acetylcholine receptors (α3-nAChRs), usually measured by radioimmunoprecipitation assay (RIPA), are detected in patients with autoimmune ... -
Pharmacogenetics and psoriasis: Is targeted treatment a possibility?
(2017)[No abstract available] -
Phosphodiesterase 4 inhibitors in immune-mediated diseases: Mode of action, clinical applications, current and future perspectives
(2017)Phosphodiesterase (PDE) 4 is a superfamily of enzymes that catalyze the hydrolysis of cyclic adenosine 3', 5'-monophosphate (cAMP), an intracellular second messenger and regulator of a wide array of genes and proteins. ... -
Primary sjögren’s syndrome and cardiovascular disease
(2020)Sjögren’s syndrome is a rheumatic autoimmune disease that primarily affects middle-aged women and runs a slowly progressing course with sicca symptoms being the prevalent manifestation. Premature atherosclerosis and increased ... -
Real-world safety and efficacy data of immunotherapy in patients with cancer and autoimmune disease: the experience of the Hellenic Cooperative Oncology Group
(2022)Background: Data on the safety and efficacy of immune checkpoint inhibitors (ICI) in patients with concurrent autoimmune diseases (AID) are limited. Methods: We performed a retrospective multicenter review of medical records ... -
Regulatory B cells: New players in inflammatory and autoimmune rheumatic diseases
(2019)Objective: Regulatory B cells (Bregs) are a new subset of B cells with immunoregulatory functions, mainly through IL-10 production. Bregs suppress inflammatory Th1 and Th17 differentiation and induce Tregs suppressing ... -
The risk of lymphoma development in autoimmune diseases: A meta-analysis
(2005)Background: The risk of development of non-Hodgkin lymphoma (NHL) in autoimmune patients has been investigated in several cohort studies. These studies revealed inconclusive results. To shed some light on this controversy, ... -
Second generation analysis of antinuclear antibody (ANA) by combination of screening and confirmatory testing
(2015)Background: For the serological diagnosis of systemic autoimmune rheumatic diseases, a two-tier approach starting with sensitive antinuclear antibody (ANA) detection by indirect immunofluorescence (IIF) on HEp-2 cells ... -
The second greek–israeli symposium on autoimmunity and rheumatology: Success through synergy
(2019)[No abstract available] -
Smoke and autoimmunity: The fire behind the disease
(2016)The association between smoke habit and autoimmunity has been hypothesized a long time ago. Smoke has been found to play a pathogenic role in certain autoimmune disease as it may trigger the development of autoantibodies ...